منابع مشابه
Optimality in DNA repair
DNA within cells is subject to damage from various sources. Organisms have evolved a number of mechanisms to repair DNA damage. The activity of repair enzymes carries its own risk, however, because the repair of two nearby lesions may lead to the breakup of DNA and result in cell death. We propose a mathematical theory of the damage and repair process in the important scenario where lesions are...
متن کاملDNA-Repair Capacity in Down\'s Syndrome
Down's syndrome (DS) is the most common chromosomal abnormality in human. Subjects with DS are known to be peridisposed to develop leukemia. The molecular basis of the association between DS and leukemia is unknown. The unscheduled DNA synthesis (UDS) test measure the ability of DNA-repair in mammalian cells after excision of a stretch of DNA containing the region of damage induced by chemical ...
متن کاملRB in DNA repair
The retinoblastoma protein (RB1) has a well-documented role as a key regulator of cell cycle progression by controlling the G1/S phase transition [1]. RB1 has also emerged as a multi-functional protein involved in a wide range of biological processes including transcriptional regulation by recruiting chromatin remodelling enzymes, DNA replication via interaction with DNA polymerase complex comp...
متن کاملBalantak metathesis and theories of possible repair in Optimality Theory
Given that oral consonants often block total vowel assimilation (Aoki 1968, Steriade 1987), this case of metathesis can be analyzed as serving to allow assimilation to apply unimpeded (cf. Broselow 2001). In terms of Optimality Theory, both the constraint driving assimilation and the constraint blocking assimilation across an oral consonant are satisfied, at the cost of violating faithfulness c...
متن کاملDNA Repair in Drosophila
Both genetic and biochemical approaches have been used to study the molecular mechanisms by which damaged DNA is repaired in a number of species. The fundamental DNA repair pathways have been functionally conserved for the most part among prokaryotes, lower eukaryotes, and higher eukaryotes, and the proteins and protein families involved in these repair processes show high degrees of amino acid...
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ژورنال
عنوان ژورنال: Journal of Theoretical Biology
سال: 2012
ISSN: 0022-5193
DOI: 10.1016/j.jtbi.2011.08.024